2-Acetamidophenol

  • Name: 2-Acetamidophenol
  • CAS: 614-80-2
  • Purity: 99%
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Details

Factory Export Top Purity 2-Acetamidophenol 614-80-2 In Stock

  • Molecular Formula: C8H9NO2
  • Molecular Weight: 151.165
  • Appearance/Colour: light brown powder 
  • Vapor Pressure: 3.64E-05mmHg at 25°C 
  • Melting Point: 205-210 °C(lit.) 
  • Refractive Index: 1.618 
  • Boiling Point: 343.1 °C at 760 mmHg 
  • PKA: 9.35±0.35(Predicted) 
  • Flash Point: 161.3 °C 
  • PSA： 49.33000 
  • Density: 1.249 g/cm3 
  • LogP: 1.42360 

2-Acetamidophenol(Cas 614-80-2) Usage

Preparation

Mix 2-Aminophenol , acetic acid and Acetic anhydride (i.e., crystals appear), and then directly heated on the fire until all dissolved, stop heating, cooling, water dilution, precipitation of crystals filtered dry, to 70-80 ℃ of ethanol recrystallization to obtain 2-acetamidophenol.

Purification Methods

Recrystallise it from water, EtOH or Est aqueous EtOH. [Beilstein 13 H 370, 13 I 113, 13 II 171, 13 III 778.]

Definition

ChEBI: 2-acetamidophenol is a member of the class of phenols that is 2-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group. A positional isomer of paracetamol which possesses anti-inflammatory, anti-arthritic and anti-platelet aggregation properties. It has a role as a platelet aggregation inhibitor, an anti-inflammatory agent, a xenobiotic metabolite, an apoptosis inducer, an antineoplastic agent and an antirheumatic drug. It is a member of phenols and a member of acetamides.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

InChI:InChI=1/C8H9NO2/c1-6(10)9-7-4-2-3-5-8(7)11/h2-5,11H,1H3,(H,9,10)

614-80-2 Relevant articles

Unprecedented Dearomatized Spirocyclopropane in a Sequential Rhodium(III)-Catalyzed C?H Activation and Rearrangement Reaction

Wang, Xiaoming,Li, Yingzi,Knecht, Tobias,Daniliuc, Constantin G.,Houk,Glorius, Frank

, (2018)

An unprecedented dearomatized spirocyclo...

1-8H-pyrano[3,2-g]benzoxazol-8-ones from 7-methoxyimino-4-methylchromene-2,8-dione

Nicolaides, Demetrios N.,Bezergiannidou-Balouctsi, Catherine,Litinas, Konstantinos E.,Malamidou-Xenikaki, Elizabeth,Mentzafos, Demetrios,Terzis, Aris

, p. 9127 - 9136 (1993)

7-Methoxyimino-4-methylchromene-2,8-dion...

Ethyl 2-Cyano-2-(2-nitrobenzenesulfonyloxyimino) Acetate (ortho-NosylOXY)-Mediated Double Beckmann Rearrangement of Ketoximes under Microwave Irradiation: A Mechanistic Perception

Dev, Dharm,Kalita, Tapasi,Mondal, Tanmay,Mandal, Bhubaneswar

, p. 1427 - 1435 (2021/01/04)

A method for Beckmann rearrangement usin...

Synthesis method of 2, 2-bis (3-amino-4-hydroxyphenyl) hexafluoropropane

-

Paragraph 0030-0032; 0037-0039, (2021/04/29)

The invention discloses a synthesis meth...

Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure-Activity Relationship and in Vivo Oral Efficacy Studies

Dziwornu, Godwin Akpeko,Coertzen, Dina,Leshabane, Meta,Korkor, Constance M.,Cloete, Cleavon K.,Njoroge, Mathew,Gibhard, Liezl,Lawrence, Nina,Reader, Janette,Van Der Watt, Mari?tte,Wittlin, Sergio,Birkholtz, Lyn-Marie,Chibale, Kelly

supporting information, p. 5198 - 5215 (2021/05/06)

A novel series of antimalarial benzimida...

Paracetamol and other acetanilide analogs as inter-molecular hydrogen bonding assisted diamagnetic CEST MRI contrast agents

Chakraborty, Subhayan,Peruncheralathan,Ghosh, Arindam

, p. 6526 - 6534 (2021/02/21)

Paracetamol and a few other acetanilide ...

614-80-2 Process route

2-benzylideneaminophenyl acetate

2-benzylideneaminophenyl acetate

water
7732-18-5

water

benzaldehyde
100-52-7

benzaldehyde

2-(acetylamino)phenol
614-80-2

2-(acetylamino)phenol

Conditions
Conditions Yield
2-(acetylamino)phenol
614-80-2

2-(acetylamino)phenol

2-ethylaminophenol
614-70-0

2-ethylaminophenol

Conditions
Conditions Yield
With sulfuric acid; durch elektrolytische Reduktion;

614-80-2 Upstream products

  • 110-86-1
    110-86-1

    pyridine

  • 1624-53-9
    1624-53-9

    2-(benzylideneamino)phenol

  • 108-24-7
    108-24-7

    acetic anhydride

  • 75-36-5
    75-36-5

    acetyl chloride

614-80-2 Downstream products

  • 132283-17-1
    132283-17-1

    1-acetylamino-2-[1]naphthoyloxy-benzene

  • 5467-64-1
    5467-64-1

    2-acetamidophenyl acetate

  • 20012-63-9
    20012-63-9

    o-(benzyloxy)aniline

  • 6296-59-9
    6296-59-9

    2-(benzamido)phenyl benzoate

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